NFL Week 16 picks, odds: Rodgers makes MVP statement on Christmas, Patriots hand Bills another bitter defeat

Week 15 is up there in terms of the most insanely bizarre NFL weeks I’ve ever seen. Obviously having two games Monday and two games Tuesday is a good start to that, 

The Texans scored 30 points in a cakewalk victory, the Lions beat the Cardinals and Tom Brady scored zero points in a home, prime-time loss. It was a weird week all around, fittingly coming in the longest week in NFL history. 

Hopefully everyone can have a winning and happy Christmas, and in the spirit of Christmas miracles, I’m going to write up fewer of these picks and toss some scores for meaningless games at the bottom. 

My ATS record against the spread this year is just awful, but 9-5 last week is strong. A strong close to the season can salvage this year ATS so let’s get hot over the holidays. 

All NFL odds are via Caesars Sportsbook

NFL Week 16 Picks

Thursday, 8:20 p.m. ET
TV: 
NFL Network | Stream: fuboTV (click here)
Follow: CBS Sports App

Latest Odds:

Tennessee Titans
+3.5

Week 15 featured plenty of underdogs barking loudly, so I’m a little hesitant to jump onto a road favorite on a short week. But the 49ers are starting to cook. Deebo Samuel appears to be the catalyst for this run game, with his presence in the backfield wrecking havoc on opposing defenses. Kyle Shanahan’s playcalling has been outstanding and the Niners appear to have a pretty good stable of backs capable of producing on a weekly basis — with Elijah Mitchell out, Jeff Wilson stepped up nicely against the Falcons. Tennessee has been good against the run this season but the 49ers should be able to stretch them horizontally. The one thing I’d be wary of if you’re backing Jimmy Garoppolo and Co.

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